#11 – Monitoring of UFH: APTT or Anti-Xa?

Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. 

In our episode this week, we will discuss with François Depasse, our Clinical Development Director, about the monitoring of UFH and the appropriate tool to do it: APTT or anti-Xa activity? 

Sources:  

• Johnson EA, Mullboy B. The molecular weight range of commercial heparin preparations. Carbohydr Res 1976; 51: 119-127 
• Hirsh J, Raschke R, Heparin and Low-molecular-weight heparin : the Seventh ACCP Conference on Antithrombotic and thrombolytic therapy. CHEST 2004; 126 (suppl 3): 188S-203S. 
• Basu D, Gallus A, Hirsh J, Cade J. A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. N Engl J Med. 1972 Aug 17;287(7):324-7. doi: 10.1056/NEJM197208172870703. PMID: 5041701. 
• Eikelboom JW, Hirsh J. Monitoring unfractionated heparin with the aPTT: time for a fresh look. Thromb Haemost. 2006 Nov;96(5):547-52. 
• Frugé KS, Lee YR. Comparison of unfractionated heparin protocols using antifactor Xa monitoring or activated partial thrombin time monitoring. Am J Health Syst Pharm. 2015 Sep 1;72(17 Suppl 2):S90-7. 
• Vandiver JW, Vondracek TG. Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin. Pharmacotherapy. 2012 Jun;32(6):546-58. doi: 10.1002/j.1875-9114.2011.01049.x. Epub 2012 Apr 24. 

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Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.

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Cecile Hourquet

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