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S3E12 - Fibrinolysis: the often missed key player of hemostasis

Presented by Audrey Carlo and Cécile Hourquet // Special guest Professor Romaric Lacroix, Professor at the University Hospital La Conception in Marseille in France

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Season 3, episode 12
9 min / Published
By Stago

Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation.

In today’s episode, our guest Professor Romaric Lacroix will explain us how fibrinolysis is important to the whole hemostasis process and how the sample fibrinolytic activity needs to be evaluated and sometimes monitored.

Link to previous podcasts:

  • S1E15 – Disseminated Intravascular Coagulation (DIC) and fibrin related markers 

Literature sources:

  • Cointe S, Vallier L, Esnault P, Dacos M, Bonifay A, Macagno N, Harti Souab K, Chareyre C, Judicone C, Frankel D, Robert S, Hraiech S, Alessi MC, Poncelet P, Albanese J, Dignat-George F, Lacroix R. Granulocyte microvesicles with a high plasmin generation capacity promote clot lysis and improve outcome in septic shock. Blood. 2022 Apr 14;139(15):2377-2391.
  • Cointe S, Harti Souab K, Bouriche T, Vallier L, Bonifay A, Judicone C, Robert S, Armand R, Poncelet P, Albanese J, Dignat-George F et Lacroix R. A new assay to evaluate microvesicle plasmin generation capacity: validation in disease with fibrinolysis imbalance. J Extracell Vesicles 2018; Jul 16;7(1):1494482
  • Vallier L, Cointe S, Lacroix R, Bonnifay A, Judicone C, Dignat-George F, Hau C.
  • Kwaan. Microparticle and fibrinolysis. Semin Thromb Hemost. 2017 Mar;43(2):129-134

 

Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.

  • fibrinolysis
  • plasmin
  • microvesicles
  • fibrinolytic cross-talk
  • ask stago
The show team
audrey.carlo
audrey.carlo
animatrice
Cecile Hourquet
Cecile Hourquet
animatrice
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