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Stago

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  1. Presented by Audrey Carlo and Cécile Hourquet // Special guest François Depasse, Clinical Development Director at Stago Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. In our episode this week, we will discuss with François Depasse, our Clinical Development Director, about the monitoring of UFH and the appropriate tool to do it: APTT or anti-Xa activity? Sources: Johnson EA, Mullboy B. The molecular weight range of commercial heparin preparations. Carbohydr Res 1976; 51: 119-127 Hirsh J, Raschke R, Heparin and Low-molecular-weight heparin : the Seventh ACCP Conference on Antithrombotic and thrombolytic therapy. CHEST 2004; 126 (suppl 3): 188S-203S. Basu D, Gallus A, Hirsh J, Cade J. A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. N Engl J Med. 1972 Aug 17;287(7):324-7. doi: 10.1056/NEJM197208172870703. PMID: 5041701. Eikelboom JW, Hirsh J. Monitoring unfractionated heparin with the aPTT: time for a fresh look. Thromb Haemost. 2006 Nov;96(5):547-52. Frugé KS, Lee YR. Comparison of unfractionated heparin protocols using antifactor Xa monitoring or activated partial thrombin time monitoring. Am J Health Syst Pharm. 2015 Sep 1;72(17 Suppl 2):S90-7. Vandiver JW, Vondracek TG. Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin. Pharmacotherapy. 2012 Jun;32(6):546-58. doi: 10.1002/j.1875-9114.2011.01049.x. Epub 2012 Apr 24.
  2. Presented by Audrey Carlo and Cécile Hourquet // Special guest Draga Tchipeva, international application specialist Welcome to Ask Stago, the weekly podcast for Hemostasis laboratory professionals. In today’s episode, with our expert Draga Tchipeva, international application specialist, Cécile Hourquet and Audrey Carlo will start questioning how we can help the laboratory to become more productive with some middleware solutions: rules engines.
  3. Presented by Audrey Carlo and Cécile Hourquet // Special guest Frédéric Brutto, product line manager Welcome to Ask Stago, the weekly podcast for Hemostasis laboratory professionals. This week, with our expert Frédéric Brutto, product line manager, Cécile Hourquet and Audrey Carlo will question HIL interferences and how the coagulation laboratory can handle them. Sources: Lippi G et al., Interference of blood cell lysis on routine coagulation testing. Arch Pathol Lab Med. 2006;130(2):181-4 Woolley A et al., Effects of haemolysis, icterus and lipaemia on coagulation tests as performed on Stago STA-Compact-Max analyser. Int J Lab Hematol. 2016; 38(4): 375-88 Plebani M, Quality Indicators to Detect Pre-Analytical Errors in Laboratory Testing, Clin Biochem Rev 2012; 3: 85-88. Salvagno GL et al, Prevalence and type of pre-analytical problems for inpatients samples in coagulation laboratory, J Eval Clin Pract. 2008 ;14(2):351-3. CLSI Hemolysis, Icterus, and Lipemia/Turbidity Indices as Indicators of Interference in Clinical Laboratory Analysis; Approved Guideline. CLSI document C56-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2012 CLSI Collection, Transport and Processing of Blood Specimens for Testing Plasma-based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline – Fifth Edition. CLSI Document H21-A5; Wayne, PA: Clinical and Laboratory Standards Institute; 2008
  4. Presented by Audrey Carlo and Cécile Hourquet // Special guest Lydie Nicoud, Director of Design and Biological Applications development Welcome to Ask Stago, the weekly podcast for Hemostasis laboratory professionals In today’s episode, with Lydie Nicoud, Director of Design and Biological Applications development, Cécile Hourquet and Audrey Carlo will try to better understand sensitivity and specificity of a diagnostic test, through some examples. Sources: CLSI, Quantitative D-dimer for the Exclusion of Venous Thromboembolic Disease, CLSI document H59-A, Wayne PA; Clinical Laboratory Standards Institute 2011 Valentine Minet, Jean-Michel Dogné, and François Mullier, Functional Assays in the Diagnosis of Heparin-Induced Thrombocytopenia: A Review Molecules 22, no. 4 (April 11, 2017): 617, https://doi.org/10.3390/molecules22040617. Cuker A, Arepally GM, Chong BH, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia. Blood Adv. 2018;2(22):3360-3392. doi:10.1182/bloodadvances.2018024489 Nagler M, Bachmann LM , ten Cate H, ten Cate-Hoek A, Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis. Blood 2016; 127 (5): 546–557. doi: https://doi.org/10.1182/blood-2015-07-661215
  5. Presented by Audrey Carlo and Cécile Hourquet // Special guest Arnaud Rouvière, Manager of the International Application Engineer team of Stago. Welcome to Ask Stago, the weekly podcast for Hemostasis laboratory professionals.  In today’s episode, we will provide you our best tips and tricks to calculate the mean normal prothrombin time for INR assay. To do so, Cécile Hourquet and Audrey Carlo are pleased to welcome Arnaud Rouvière, Manager of the International Application Engineer team of Stago. Source: WHO technical report series ; no. 979, 2013
  6. Presented by Audrey Carlo and Cécile Hourquet // Special guest Alexandre Rousseaux, Marketing manager and the cybersecurity referent of Stago Global Marketing Welcome to Ask Stago, the Podcast providing expert answers to your expert questions. In today’s episode, our cybersecurity referent Alexandre Rousseaux will explain us how cybersecurity is impacting lab practices every day and why we are all talking about it. Follow us on LinkedIn In or Twitter
  7. Presented by Audrey Carlo and Cécile Hourquet // Special guest Debra Bryant, honorable mention recipient of the WTD 2020 Ambassador of the year award Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. Today episodes are broadcasted from October 13, which is the World Thrombosis Day. Our episodes are thus dedicated to raise awareness about thrombosis symptoms and management, through the interview of 3 “thrombosis survivors”: Debra Bryant, honorable mention recipient of the WTD 2020 Ambassador of the Year Award, Todd Robertson, one of the most active WTD Ambassadors within the US, and Chris Pugh, who lives in the UK and very recently started his "living with a clot" journey. Get involved in the WTD movement https://www.worldthrombosisday.org/ Follow us on LinkedIn In or Twitter Lear more about Debra online patient group
  8. Presented by Audrey Carlo and Cécile Hourquet // Special guest Todd Robertson, WTD Ambassador Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. Today episodes are broadcasted from October 13, which is the World Thrombosis Day. Our episodes are thus dedicated to raise awareness about thrombosis symptoms and management, through the interview of 3 “thrombosis survivors”: Debra Bryant, honorable mention recipient of the WTD 2020 Ambassador of the Year Award, Todd Robertson, one of the most active WTD Ambassadors within the US, and Chris Pugh, who lives in the UK and very recently started his "living with a clot" journey. Get involved in the WTD movement Follow us on LinkedIn In or Twitter
  9. Presented by Audrey Carlo and Cécile Hourquet // Special guest Chris Pugh Welcome to Ask Stago, The Podcast dedicated to provide expert answers to your expert questions in coagulation. Today episodes are broadcasted from October 13, which is the World Thrombosis Day. Our episodes are thus dedicated to raise awareness about thrombosis symptoms and management, through the interview of 3 “thrombosis survivors”: Debra Bryant, honorable mention recipient of the WTD 2020 Ambassador of the Year Award, Todd Robertson, one of the most active WTD Ambassadors within the US, and Chris Pugh, who lives in the UK and very recently started his "living with a clot" journey. Get involved in the WTD movement Follow us on LinkedIn In or Twitter
  10. Presented by Audrey Carlo and Cécile Hourquet // Special guest François Depasse, Clinical Development Director at Stago Welcome to Ask Stago, the Podcast providing expert answers to your expert questions. In today’s episode, with François Depasse our Clinical Development Director, we will discuss the selection of a cut-off for D-dimer assay in venous thromboembolism exclusion diagnosis. Sources: Pernod G, Maignan M, Marlu R. Questioning the use of an age-adjusted D-dimer threshold to exclude venous thromboembolism: analysis of individual patient data from two diagnostic studies: comment. J Thromb Haemost 2016; 14: 2553–4. Stavros V Konstantinides, Guy Meyer, Cecilia Becattini, Héctor Bueno, Geert-Jan Geersing, Veli-Pekka Harjola, Menno V Huisman, Marc Humbert, Catriona Sian Jennings, David Jiménez, Nils Kucher, Irene Marthe Lang, Mareike Lankeit, Roberto Lorusso, Lucia Mazzolai, Nicolas Meneveau, Fionnuala Ní Áinle, Paolo Prandoni, Piotr Pruszczyk, Marc Righini, Adam Torbicki, Eric Van Belle, José Luis Zamorano, ESC Scientific Document Group, 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC), European Heart Journal, Volume 41, Issue 4, 21 January 2020, Pages 543–603, https://doi.org/10.1093/eurheartj/ehz405.
  11. Presented by Audrey Carlo and Cécile Hourquet // Special guest Minh-Lan Nguyen, MyExpertQC product line manager at Stago Welcome to Ask Stago, the Podcast providing expert answers to your expert questions. In today’s episode, thanks Minh-Lan Nguyen, product line manager, we will help you to differentiate and understand the goal of the externalized internal quality control (eIQC) and external quality assessment programs (EQA).
  12. Presented by Audrey Carlo and Cécile Hourquet // Special guest François Hamon, Directeur Business Developpement at Stago Welcome to Ask Stago, the podcast providing expert answers to your expert questions. In this week ‘s episode with our expert François Hamon, we will provide you information about how infection with COVID-19 affects coagulation and how these coagulation abnormalities should be monitored. Sources: Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 2020;18:844–7. Moores LK, Tritschler T, Brosnahan S et al, Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019, CHEST Guideline and Expert Panel Report, CHEST 2020; 158(3): 1143-63
  13. Presented by Audrey Carlo and Cécile Hourquet // Special guest François Hamon, Director of Business Development at Stago Provide guidelines about the best practices to handle samples from COVID-19 patients and answer FAQ questions from the field about general management such as preparation of sample and HIL interferences induced by COVID-19. Sources: Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA. 2020;323(18):1843–1844. doi:10.1001/jama.2020.3786
  14. Stago

    Ask Stago

    Ask Stago: EXPERT ANSWERS TO YOUR EXPERT QUESTIONS Ask Stago is the weekly podcast for Hemostasis laboratory professionals. In less than 10 minutes, Cécile Hourquet and Audrey Carlo host special guests to provide “expert answers to your expert questions”. Stay abreast on hot topics in Hemostasis through Ask Stago! Contribute to the discussion by sending your questions to ask@stago.com Follow us on LinkedIn or Twitter
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